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Gene Therapy

Gene Therapy

Gene therapy is the future therapy!

At BIB, we are dedicated to providing high quality and on-time delivery for AAV material and services. Our highly experienced technical team and well-versed project management service will ensure your satisfaction at the completion of your project!

Gene Therapy, man and bioreactor

We offer the following Gene Therapy Services:

Adeno-Associated Virus (AAV) focused technology.
We will use advanced AAV-focused technology to help you with your business. We offer plasmid generation, scale-up, gene editing, AAV host cell screening, and AAV titer optimization.

Vector design, AAV production and analytical characterization.
We not only provide AAV-focused technology, but also provide Designing, Expression & Purification. We provide analytical testing services for AAV identity, quantification, and purity/impurity characterization by techniques such as by qPCR, ELISA, gel electrophoresis, and HPLC.

List of Gene Therapy Services

Vector Services

  • Design and Generation
  • Scale up production
  • Plasmids
  • Adenovirus
  • Retrovirus
  • Lentivirus
  • AAV

Virus Production

  • Transient expression
  • Stable expression
  • Mammalian/Insect CL
  • USP & DSP process development
  • Process Characterization
  • Scale up/down process development
  • cGMP manufacturing

Analytical Characterization Services

• ELISA for titer
• qPCR for titer
• SDS-PAGE and DNA agarose gels
• Dynamic light scattering (DLS)
• ddPCR
• Cell-based infectivity and potency assays
• Residual host cell protein and residual host cell DNA quantitation
• Endotoxin quantitation

Gene Editing

  • Knockout/Knockdown

Virus Purification

  • Affinity, TFF
  • IEX Chromatography
  • Ultracentriguation

State-of-the-art facilities

Boston Institute of Biotechnology provides full spectrum services which utilize next generation technologies, QbD and DoE methodologies. Our experienced scientists deliver the highest quality project results in a timely and efficient manner. We pride ourselves in achieving milestones for our customers with a focused mindset on commercialization.

Gene Therapy, man and bioreactor

Our Strengths

We provide Gene Therapy services with State-of-the-art facilities and high throughput technologies to support our clients with accurate and high standard of quality.

  • One stop service for pDNA, gene therapy and recombinant AdV/AAV vector production and vaccines from integrated production site.
  • Well established multi-expression suspension and adherent production platforms using HEK 293 & SF9 (and microbial fermentation platforms for pDNA production)
  • Efficient and robust AAV purification platform process
    QbD-driven DoE optimization system to enhance and stabilize AAV vector production
  • Robust and quantitative analytical assays for viral vectors
  • Experience with drugs in preclinical and throughout clinical development
  • First gene therapy CMC service provider in the world, and our clients include top multinational pharmaceutical companies
  • GS/DHFR system vector design and generation
  • Stable Cell Lines Development with competitive timeline
  • Stability Testing
  • Research Cell Banking
  • Master Cell Banking
  • Transient Expression
GMP Production - 10kl

Contact our team today!