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Gene Therapy

Gene Therapy

Gene Therapy Infographic

Gene therapy is the future therapy!

At BIB, we are dedicated to providing high quality and on-time delivery for AAV material and services. Our highly experienced technical team and well-versed project management service will ensure your satisfaction at the completion of your project!

We offer the following Gene Therapy Services:

Adeno-Associated Virus (AAV) focused technology.
We will use advanced AAV-focused technology to help you with your business. We offer plasmid generation, scale-up, gene editing, AAV host cell screening, and AAV titer optimization.

Vector design, AAV production and analytical.
We not only provide AAV-focused technology, but also provide Designing, Expression & Purification. We provides analytical services for AAV identity, quantification, purity/ impurity, infectivity and safety by qPCR, ELISA, gel electrophoresis, HPLC based methods

List of Gene Therapy Services

Vector Services

  • Design and Generation
  • Scale up production
  • Plasmids
  • Adenovirus
  • Retrovirus
  • Lentivirus
  • AAV

Virus Production

  • Transient expression
  • Stable expression
  • Mammalian/Insect CL
  • USP & DSP process dev
  • Process Characterization
  • Scale up/down
  • GMP manufacturing

Analytical Services

  • qPCR
  • ddPCR
  • Cell-based infectivity and potency assay
  • HCP, resDNA
  • Endotoxin

Gene Editing

  • Knockout/Knockdown

Virus Purification

  • Affinity,
  • IEX Chromatography
  • TFF
  • Ultracentriguation

State-of-the-art facilities

Boston Institute of Biotechnology provides full spectrum services which utilize next generation technologies, QbD and DoE methodologies. Our experienced scientists deliver the highest quality project results in a timely and efficient manner. We pride ourselves in achieving milestones for our customers with a focused mindset on commercialization.

cell culture development

Our Strengths

We provide Gene Therapy services with State-of-the-art facilities and high throughput technologies to support our clients with accurate and high standard of quality.

  • One stop service for pDNA, gene therapy and recombinant AdV/AAV vector production and vaccines from integrated production site.
  • Well established multi-expression suspension and adherent production platforms using HEK 293 & SF9 (and microbial fermentation platforms for pDNA production)
  • Efficient and robust AAV purification platform process
    QbD-driven DoE optimization system to enhance and stabilize AAV vector production
  • Robust and quantitative analytical assays for viral vectors
  • Experience with drugs in preclinical and throughout clinical development
  • First gene therapy CMC service provider in the world, and our clients include top multinational pharmaceutical companies
  • GS/DHFR system vector design and generation
  • Stable Cell Lines Development with competitive timeline
  • Stability Testing
  • Research Cell Banking
  • Master Cell Banking
  • Transient Expression
cgmp production bib cdmo

Get in touch and let us
know how we can help