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Principal Scientist

Downstream Process Development

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Peng JiaoCEO, Boston Institute of Biotechnology

About the job

Position Summary:

A Principal Scientist at BIB is a highly motivated individual that works as the supervisor/project lead for one or more relevant projects, and mentors the involved junior scientists. Through significantly contributing to the operation of BIB and to strategically defining the direction of growth of BIB, the Principal Scientist at BIB is among the core members that significantly influence the performance and growth of BIB.


  1. Provide technical expertise and leadership in planning, designing, and conducting experiments, analyzing data and documenting results towards development and optimization downstream processes and/or achieving goals for cross functional development teams
  2. Provide technical expertise and leadership in the technologically innovative efforts of the relevant project teams
  3. Supervise setup, operation, and routine maintenance of AKTA, Process skid and equipment. Monitor processes to ensure consistency and reliability
  4. Work independently, analyze and interpret experimental data, and present/document experimental results at meetings. Provide reports and prepare scientific presentations as needed. Write/revise batch records and technical reports
  5. Play a lead role in strategically maintaining group awareness of relevant scientific literature and new technologies and business trends. Participate in/lead the evaluations of new technologies and their potential applications and business impacts. Maintain substantial knowledge of state-of-the art principles and theories and contribute knowledge base through literature review, conferences attendance and publication
  6. Provide excellent judgements in the decision-making processes existing in the execution of a project
  7. Provide technical coaching (matrix management) of and motivate junior staff members to high performance by providing mentoring, training, and appropriate supervision in process development activities
  8. Manage resource planning and projects with excellent financial, timing, and priority awareness


  1. Ph.D./MS/BS degrees in biology, biochemistry, biomedical/biochemical engineering, or related fields
  2. Ph.D. with ≥11 years or MS with ≥14 years or BS with ≥16 years of experience in upstream bioprocess related process development, scale-up and tech transfer to cGMP manufacturing facility in biotechnology, pharmaceutical or related environment; Proven record of technical leadership
  3. Excellent and extensive knowledge/experience of cGMP working environment
  4. Excellent technical, organizational, and communication skills, as well as the strong ability to develop creative solutions to challenging problems
  5. Proven strong ability to work in a fast-paced environment with demonstrated capacity to juggle multiple competing tasks and demands
  6. Proven strong judging ability when a decision-making is needed during the execution of a project
  7. Outstanding teamwork/collaboration spirits and excellent ability to communicate appropriately and effectively
  8. SME in designing and developing primary recovery, chromatography, ultrafiltration/diafiltration, viral filtration/inactivation, and formulation for biologics drug substances development
  9. Strong hands on experience with AKTA purification systems (purifier, explorer, AKTA Pilot and Process skid) is required, ability for AKTA equipment trouble shooting is required.
  10. SME with ion exchange, hydrophobic, mixed mode and affinity chromatography with AKTA purification systems, TFF process and filtration development
  11. Excellent strategic views in judging business trends & their potential impacts, and proactive attitude to learn new technologies and manage changes in process development and process scale-up
  12. Proven excellent management experience and leadership aptitude, and excellent financial awareness
  13. Client focused, quality, results, productivity, and efficiency oriented, and science and innovation driven
  14. Advanced written skills
  15. Attention to detail, and the ability to multitask
  16. Proficient with the use of MS Office software (MS Excel, MS Word, MS Powerpoint) and statistical DOE software including JMP, Minitab, Design Expert etc)
  17. Flexible and results oriented
Projects Completed
Years of Experience
Growth YoY

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