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Associate Scientist

Downstream Process Development

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Peng JiaoCEO, Boston Institute of Biotechnology

About the job

Position Summary:

The Associate Scientist is responsible for development and execution of downstream related projects with moderate direct supervision. The individual reports to a more senior scientist level or above on relevant projects. The individual will provide expertise in the development and optimization of downstream processes.


  1. Setup, operate, and maintain the downstream bioprocess related equipment, such as AKTA, TFF system, centrifuge, filters etc., to carry out the experiments of the relevant projects
  2. Develop, optimize, and characterize downstream processes, as needed, to improve the purification yield and product quality
  3. Record, analyze and report related experimental data
  4. Resolve technical or equipment problems that may arise
  5. Order the needed materials and supplies for the relevant projects
  6. Work with the other project team members to solve any arising problems during the project period
  7. Attend the regular group meetings to update the progresses of the projects
  8. May function as the Downstream Development group’s representative/team lead on cross-functional team projects
  9. Train PD or manufacturing staff to perform downstream processes, as needed
  10. Maintain all notebooks and documentation according to department standards.
  11. Write development reports, SOPs, and batch records
  12. Ability to work well in a team environment. and independently as required
  13. Ability to prioritize and manage multiple activities while maintaining quality
  14. Ensure and promote safe environmental and laboratory practices


  1. BS or MS degree in biology, biochemistry, biomedical/biochemical engineering, or related fields
  2. MS with ≥1 year or BS with ≥3 years of experience with downstream processes including primary recovery, chromatography, ultrafiltration/diafiltration, viral filtration/inactivation, and formulation for biologics drug substances development
  3. Hands on experience with AKTA and TFF system is preferred
  4. Experience with ion exchange, hydrophobic, mixed mode and affinity chromatography with AKTA purification systems
  5. Able to work independently and on cross-functional teams
  6. Good equipment troubleshooting skill
  7. Flexible and results oriented
  8. Excellent written and verbal communication skills
  9. Excellent math and MS Office software skills (MS Excel, Word, PowerPoint)
Projects Completed
Years of Experience
Growth YoY

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